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Stress axis is a restrictive term since stress activates a hypothalamic platform, composed of various nuclei, involving numerous mediators that are networked together, with far-reaching central and peripheral effects

2.2.1 Initiation and progression of neurodegenerative diseases Each neurodegenerative disease has distinct initiating pathological proteins and vulnerable neuronal populations, but a common theme is that the accumulation of protein aggregates and resulting neuronal stress elicits a sustained immune response in the brain