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In addition, these tumors were enriched with immune modulators such as programmed cell death 1 ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1), further underscoring the immunosuppressive nature of the stromal environment ( Possibly as a strategy to reduce cholesterol intake, LDLR expression is significantly lower in total CD8 + colorectal tumor infiltrating lymphocytes (TILs) compared to active CD8 + TILs