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The extended half-lives of weekly formulations mean these medications do accumulate to some degree with repeated dosing until reaching what is termed 'steady state'a predictable, stable concentration that optimises therapeutic benefit whilst minimising adverse effects

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The most well-known GLP-1 medications available in the US in 2026 are Wegovy and Ozempic (both contain semaglutide), and Zepbound and Mounjaro (both contain tirzepatide, a dual GIP/GLP-1 agonist)