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Severe depression, suicidal risk, psychosis, mania, dangerous aggression, dehydration, malnutrition or kidney impairment require stabilization before chelation, prolonged fasting, extensive sauna or complex detoxification protocols

As to be expected with any such complex regulation, the likelihood of errors that result in the impairment of function are increased

Proper dose calculation is especially important when working with research-grade materials where concentrations may differ from commercial preparations

As was previously mentioned, levels of GH and IGF-1 steadily decrease over a lifespan, and with the lower hormone levels comes a myriad of side effects such as increased fat mass, cardiovascular dysfunction, decreased muscle mass, and declined cellular protein synthesis