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As the primary source of ROS, mitochondria can stimulate cells to undergo ferroptosis
In contrast, reduced and oxidized glutathione added to blood samples, cells or plasma remained intact
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This phenomenon is particularly observed in clear cell carcinomas within EAOC ( The frequent activation of the PI3K/AKT pathway in endometrioid and ovarian clear cell carcinomas is a result of mutations in PIK3CA, AKT, and PTEN, leading to their inactivation ( The early progression of endometriosis involves the inactivation of the tumor suppressor gene protein phosphatase and tension homologue (PTEN) at locus 10q23.3, as identified in previous research ( The upregulation of Fibroblast growth factor receptor 2 (FGFR2) expression in ovarian endometriosis demonstrates aberrant elevation during the progression towards malignancy ( Table 1 )
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