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The theoretical mechanism involves: Transdermal absorption of molecules through the stratum corneum (outer skin layer) Conversion to NAD+ within cells via salvage pathways Claimed sustained release over several hours, potentially avoiding first-pass hepatic metabolism Potential localised or systemic effects depending on absorption efficiency Manufacturers claim that transdermal delivery offers advantages over oral supplements, including better bioavailability and more consistent blood levels

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Drucker DJ

USA 109 , 1439314398 (2012)

Flexibility matters, especially as the science evolves and new treatment options become available