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Supplementation The control group participated in the training protocol without any supplementation, whereas two other groups were supplemented with either 4000 mg l-leucine per day or 1000 mg l-carnitine- l-tartrate in combination with 3000 mg l-leucine per day throughout the study period

The preliminary cardiovascular safety data for DPP-4 inhibitors are promising, and, if the results of long-term cardiovascular studies demonstrate reductions in hard cardiovascular end points, then this may consolidate the position of the DPP-4 inhibitors as the second-line choice for combination with metformin