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To address this, future interventions should prioritize integrated synbiotic therapies, combining carefully selected probiotics with specific prebiotics to enhance microbial engraftment, stabilize gut ecology, and reinforce host metabolic and immune homeostasis (Balthazar et al., 2022)

26 More importantly, unlike caloric restriction, LCA does not induce the adverse effect of muscle loss observed in caloric restriction, offering a superior strategy to enhance healthspan

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