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3 OBESITY AS AN INFECTION CONTROL RISK FACTOR THE EVIDENCE Understanding why obese patients have higher HAI rates is the foundation of targeted IC intervention: Immune Dysfunction: Adipose tissue is not metabolically inert it is an active endocrine organ that produces pro-inflammatory cytokines (TNF-, IL-6, leptin) that paradoxically impair pathogen-specific immune responses

Combined with our other results, this suggests that the chemotherapeutic action of PAT is more likely to occur through inhibition of parasite TGR and than of PFK, or that inhibition of both enzymes provides a synergistic antiparasitic affect

Moreover, xCT/SLC7A11 inhibition has a deleterious effect on TNBC cell proliferation, and it is proposed that this effect is mediated by GSH depletion [20]

Long-term NSAIDs Regular oral NSAID use raises the risk of stomach ulcers, kidney problems, and cardiovascular events