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Portugal developed a national guideline for L-C19 management, with focus on multidisciplinary management in primary care

Zepbound is approved for long-term use

Both sEV-semaglutide and sEV-tirzepatide significantly reduced blood glucose levels compared to the control group (Figure 5), suggesting that sEVs may play a similar role as SNAC in enhancing the oral availability of semaglutide, thereby reducing blood glucose levels

Second, among GLP-1 receptor agonists, only liraglutide and dulaglutide showed increased trends in the risks of overall thyroid disorders compared with placebo and other antidiabetic drugs