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Gastrointestinal Side Effects are the predominant category of adverse reactions: Nausea affects approximately 12-24% of diabetes patients and up to 30% of weight management patients, typically most severe during the first few weeks of treatment or following dose increases Diarrhea occurs in 13-17% of diabetes patients and up to 24% of weight management patients Vomiting is reported by 6-10% of diabetes patients and up to 12% of weight management patients, particularly at higher doses Constipation affects 6-11% of diabetes patients and up to 17% of weight management patients Dyspepsia and abdominal pain occur in 6-9% of patients Decreased appetite is common and contributes to the medication's weight loss effects Gastroesophageal reflux disease (GERD) occurs in some patients, particularly at higher doses These gastrointestinal symptoms typically diminish over time as the body adapts to the medication

The financial impact on Medicare is tempered by a 2003 federal law that prevents the government health insurance program from covering weight-loss medications.The drugs can be added to formularies if prescribed for another medically accepted indication, such as to treat type 2 diabetes or reduce heart risk, but patients cant get it if their only medical issue is obesity

Therefore, if you follow a predominantly plant-based diet, supplementation with L-carnitine is recommended, especially for those who regularly engage in active exercise

Another study showed that glutathione therapy helped the body use insulin better and lowered signs of oxidative stress, which is linked to metabolic syndrome a major cause of NAFLD Specifically, glutathione benefits NAFLD patients in the following ways: Reduces oxidative stress