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Nitric oxide mediated inhibition of antigen presentation from DCs to CD4 + T cells in cancer and measurement of STAT1 nitration

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However, excess free radicals created by the immune system and environmental toxins severely damage cells

Increased knowledge of how bacteria and bacterial products such as endotoxin cross the epithelial barrier should yield data that facilitate the discovery of treatments aimed at abrogating the most feared complications of systemic endotoxemia, namely SIRS and MOF, whereas further study of paracellular permeability could likely lead to breakthroughs in the prevention of toxigenic diarrhea, a cause of substantial morbidity and mortality worldwide [87]