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GNE inhibition results in hyposialylation of IGF-1R Since the key function of GNE is epimerization and phosphorylation of precursors in the sialic acid biosynthetic pathway, absence of functional GNE would cause hyposialylation and affect sialylation of cell surface receptors 15,30

PlexusDx's dual-compound GLP-Squared formulation combines semaglutide and tirzepatide in a single injection at $289/mo month-to-month, or from $249/mo on the 6-month plan, targeting patients whose genetic profile suggests benefit from both mechanisms

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STEP 3 | Ongoing Support