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Table of Contents The evolution of GLP-1 therapy into chronic treatment Gastrointestinal tolerability beyond three years Discontinuation trends and persistence patterns Strategies for maintaining long-term GLP-1 safety Clinical implications for chronic therapy The Evolution of GLP-1 Therapy Into Chronic Treatment In the early years of incretin-based therapy, clinicians often viewed GLP-1 receptor agonists as add-on treatments for patients with uncontrolled type 2 diabetes