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Importantly, participants in the medications studies will be treated for 12 months and studied at the end of active treatment and again after a 3 month medication washout period to determine whether improvements in beta cell function can be maintained when the active intervention is no longer in place

Treatment of hyperlipemic mice with the ferroptosis inhibitor ferrostatin-1 (Fer-1) significantly decreases the development of atherosclerosis in ApoE-/- mice fed HFD for 1216 weeks 79

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