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Pravastatin Treatment and Antioxidants Supplementation Thirty-day-old male LDLr -/- mice received pravastatin (Medley Ltda, Brazil) diluted in the drinking water (400 mg/L) during 3 months as previously described (Lorza-Gil et al., 2016)

Central to this process is the Nuclear Factor Erythroid 2Related Factor 2 (Nrf2)-ARE signaling pathway, which significantly enhances the activity of key antioxidant enzymes

The highest score of 10 points reflects the greatest impairment, while the lowest score of 0 points represents normal forelimb function

At low intracellular concentrations (0.011 M), H 2 S injects electron equivalents into the mitochondrial electron transport chain (mETC) by reducing quinone to quinol via sulphide:quinone oxidoreductase (SQR), ultimately stimulating ATP production