tirzepatide and kidney stones (Zepbound) showed improved function in obese patients with both chronic kidney disease #heartfailure with preserved ejection fraction, highlighting its potential to address this high-risk patient population. Read more: https Nephrology General Nephrology articles page

After receiving cyclosporine treatment, reactive species, redox imbalance, and mitochondrial DNA damage, significantly increased in rat hepatocytes (Moran et al., 1998

However, it was suspected early on that incretin action was exerted by more than a single hormone

- IP treated: animals subjected to fasting for 5 consecutive days and receiving a daily intraperitoneal administration of L-carnitine or L-lysine (HCl) or L-carnitine + L-lysine (HCl), in a volume of 0.2 ml per 100 g of body weight

Orforglipron is the first small-molecule GLP-1 receptor agonist, taken without food and water restrictions, to successfully complete a Phase 3 trial