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The gut and beyond: GI effects and other tissues In the gastrointestinal tract, the receptor appears in the Brunners glands of the duodenum, in parietal cells, and in gastric smooth muscle, where it slows gastric emptying

Moreover, treatment with GLP-1 resulted in a decrease of lipopolysaccharide (LPS)-induced activation of the BV-2 microglial cell line, accompanied by a decrease in TNF- secretion [63]

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Start your intake How GLP-1 Medications Trigger Gastrointestinal Changes GLP-1 receptor agonists slow gastric emptying and increase colonic fluid secretion, both mechanisms contributing to improved blood sugar control