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Many physicians recommend trying GLP-1 medications before considering surgical options, especially for women with BMI 30-40

They can help you figure out how Ozempic fits into your treatment plan and if other steps, like physical therapy or strength training, are needed to protect your joints

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Metabolomic profiles showing elevated citrate, isocitrate, and aconitate with relatively lower level of -ketoglutarate and malate suggest a potential block in the tricarboxylic acid (TCA) cycle distal to aconitate, a metabolic hallmark of inflammatory macrophages