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Research indicates that upon MC1R binding, MT-1 triggers the cAMP signaling cascade, leading to activation of protein kinase A (PKA) and subsequent upregulation of microphthalmia-associated transcription factor (MITF)

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Upon binding, this receptor activation may trigger a series of intracellular events that potentially culminate in the release of stored growth hormone from somatotroph cells (GH-producing cells) in the anterior pituitary

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