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Macrophage activation and foam cell formation may explain the elevated CRP serum levels and contribute to disease progression (Figure 3)

Insulin resistance, hyperandrogenemia, and oxidative stress imbalance are the three critical pathological mechanisms involved in the development of PCOS, forming a vicious cycle [37, 38] that perpetuates the diseases progression

Another study investigated the anti-inflammatory and ocular surface-protective effects of 1,5-dicaffeoylquinic acid (1,5-diCQA), a polyphenolic component from Pseudognaphalium affine , on DED symptoms