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Serum B12 above 300 pg/mL is often interpreted as normal (6) Serum B12 levels between 200 and 300 pg/mL are considered borderline (in which case further enzymatic testing may be helpful for diagnosis) (6) Enzymatic testing: serum levels of MMA and homocysteine should both be elevated if B12 deficiency is present

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Additionally, vitamin B12 is necessary for the metabolism of cells throughout the body, including those involved in energy production and DNA synthesis