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The diagram below illustrates a generalized picture of how enzymes work

Blood 111 , 36843691 (2008)

Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, et al

Wang Y, Wang T, Montero-Pedrazuela A, Guadao-Ferraz A, Rausell E (2023) Thyroid hormone transporters MCT8 and OATP1C1 are expressed in pyramidal neurons and interneurons in the adult motor cortex of human and macaque brain