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Mudgal and coworkers demonstrated that in Swiss mice treated with LPS, a one-week treatment with a low dose of caffeine and a low dose of caffeic acid produced anxiolytic effects in the OFT and DLB, antidepressant effects in OFT and DLB, and anti-inflammatory effects with reduction of IL-6 and TNF-alpha in serum and brain [34]

Controls simultaneously received an equivolume of saline (5.0 ml/kg ip) or water only (12 ml/rat/day)

As a result, high-quality RWD and RWE are expected to play an increasingly important role throughout the product lifecycle, supporting reimbursement, market access, and post-launch evidence generation

Vitamin C helps your body build new collagen