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These findings collectively suggest that low-dose sirolimus possesses a favorable risk-benefit ratio in RA patients across varying disease activity states, supporting its potential as an immunomodulatory adjunct in RA management

10.1186/s13018-019-1242-6 86 PetekM.SikiricP.AnicT.BuljatG.SeparovicJ.Stancic-RokotovD.et al (1999)