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Drugs without GIPR activity (semaglutide, orforglipron, survodutide, pemvidutide) are plotted along the bottom axis

The longevity peptide research community has long understood that short-term discomfort during a protocol often precedes long-term benefit

They are believed to enhance matrix synthesis, stimulate osteoblast differentiation, and suppress osteoclast activity, offering potential for osteoporosis prevention and treatment (127)