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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Ma J, Mathur K, Muldoon J, Ghabril M, Chalasani N, Vuppalanchi R