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For the comparisons between the two groups, an independent t-test or Mann-Whitney U test was used depending on the data distribution

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In clinical trials involving 17,183 patients, 50.2% of participants treated with GLP-1 receptor agonists lost at least 5% of their body weight, and 17.5% achieved a weight loss of 10% or more, both figures being significant compared to a placebo group

47 TYR and TYRP1 are the main downstream targets of MITF implicated in melanin production, whereas SOX10 and PAX3 are a canonical melanocytic lineage-specific transcriptional factor of MITF