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A commenter interpreted CMS' proposal as requiring covered entities to begin submitting data fields to the 340B repository in 2026, and stated that this requirement would have significant implications for the Indian Health System (IHS) as IHS facilities operate with limited staff and resources and the commenter stated that this data collection could be used to restrict 340B savings

However, we believe fewer measures would be considered topped-out in ASM given the mandatory reporting of all quality measures applicable for each ASM cohort

Fibroblast cell-culture studies have characterized proliferation, migration, collagen synthesis, and gene-expression endpoints

Over 68 weeks in the REDEFINE trials, cagrilintide 2.4 mg alone achieved approximately 10.8% body weight reduction