percentage of weight loss with semaglutide Long-term effects in obesity without diabetes in the SELECT trial Slimming Down with Semaglutide: A

A more conservative approach may be worth discussing with a provider if you have a history of GI sensitivity or conditions like IBS, have previously stopped GLP-1 therapy because of side effects, are an older adult (who may be more sensitive to GI effects), or are starting treatment at a lower BMI where the full therapeutic dose may not be necessary

Cancer Lett 269:315325

The significant decrease in blood pressure with SGLT2 inhibitors may provide a further advantage for obese patients when we take into account the high prevalence of hypertension among obese patients and the related cardiometabolic impact [60]