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We look forward to ongoing large-scale clinical trials of both pharmacologic and device-based therapies which are critical in advancing our understanding of this highly prevalent disease

Mir-155-5p and related target genes of PCOS are concentrated in the insulin-sensitive pathway of the ovary, and Mir-222 is also positively correlated with serum insulin levels, suggesting their potential value as biomarkers of PCOS [115]

Furthermore, there has been an indication of tirzepatide reducing liver fat, and improving nephrotic outcomes as evidenced by the lower urine albumin: creatinine ratio and the slower decline of estimated glomerular filtration rate in people with T2DM [56]

10.1016/s0140-6736(23)01301-6 [DOI] [PMC free article] [PubMed] [Google Scholar] Pratley R., Saeed Z