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3b), meaning that DFO and CoCl 2 act mostly on iron transport activity whereas curcumin acts intracellularly with an almost strict chelating activity (immobilization of the free intracellularly available Fe 2+ )

This proteolytic process results in structural rearrangement of S-protein and allows fusion between the viral envelope and host cell membrane 57,76 , which cumulatively drives an efficient internalization (infection) of SARS-CoV-2 into target host cells 55,77

ART-nave patients showed altered haematological indices when compared with patients on ART and the seronegative controls

It also promotes liver detoxification