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The presence of comorbidities can significantly impact the pharmacokinetics of Vitamin B12, making it essential to adjust dosing protocols. Expert Opinion on Vitamin B12 Therapy Genetic Factors Affecting B12 Metabolism Genetics play a role in how well someone can use Vitamin B12

A reaction that depletes cellular NAD+ pools and methyl donor availability

After the initial phase, your treatment will depend on whether your vitamin B12 shortage is caused by your food or whether it is resulting in any neurological issues, such as issues with thinking, memory, and behaviour, Dr Aravinda commented

However, the exact molecular target remains unidentified, and efficacy has not been demonstrated in humans