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The attenuation of effect with tachyphylaxis primarily reduces the delay in gastric emptying, with long-acting formulations showing less consistent slowing of emptying compared to short-acting agents

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For example, Brazil's health authorities penalized an importer selling allulose at a meaningful scale and issued a formal resolution prohibiting the import and sale of this " novel ingredient ." As of January 2026, allulose is banned in some major natural & organic food grocery stores in America, such as Whole Foods Market