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In general, the transporter-mediated passage of compounds across the cellular membrane can be investigated using several methods including in vivo cerebral microdialysis technique, in situ brain perfusion technique and PET imaging in transporter-knockout animals or using selective transporter inhibitors and substrates (112, 118, 196,197,198)

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If a patient's insurance plan provides robust coverage for Wegovy but not for Zepbound, semaglutide becomes the more practical and affordable option, offering significant weight loss benefits without the financial strain