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Early after liver resection, regeneration ability is insufficient due to the shortage of liver cells and liver volume, high pressure in the portal vein, long sustained time and small liver syndrome that is characterized by postoperative liver dysfunction, high blood bilirubin with prolonged cholestasis, blood coagulation disorders, portal hypertension, and the emergence of serious ascites

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In human plasma GHK is present at about 200 micrograms/liter in men of age 2025 but declines to 80 micrograms/liter by age 6080