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These results suggest that VPA seemed to protect retinal ganglion cells (RGC) from ONC by hindering neuronal apoptosis, presumably, via the initiation of HDAC inhibition and BDNF-TrkB signaling (Zhang et al., 2012)

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Radiologically, MMNSTs typically show T1 hyperintensity and T2 hypointensity on MRI due to intratumoral melanin ( For metastatic MMNST, ifosfamide plus doxorubicin is the most reported chemotherapy regimen, while fotemustine has shown partial remission in one case ( Anlotinibs efficacy in MPNSTs was recently suggested by Chen ( The prolonged disease control observed in this patient is likely attributable to the synergistic interplay among anlotinibs multifaceted antitumor mechanisms