The most commonly reported side effects in Phase 2 trials are gastrointestinal: nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation
To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction
On the highest 12 mg dose, participants lost an average of 28.3% of their body weight, equivalent to approximately 70.3 pounds
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