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Endocr Rev
Patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMMs) offer more physiological insights but are limited by cost, long development times, and species-specific differences [40,41,42]
A study using Framingham Heart Study data suggested that men in the study appeared to have a lower risk for dementia due to survival bias, in which the men who survived to age 65 or beyond and were included in the study were the ones with a healthier cardiovascular risk profile (men have a higher rate of death from cardiovascular disease in middle age than women) and thus a lower risk for dementia
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