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If the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be awakened, call 911 immediately for emergency medical assistance

Upon oxidative challenge, Nrf2 dissociates from Keap1, translocates to the nucleus, and binds to the antioxidant response element (ARE), initiating the transcription of cytoprotective genes such as heme oxygenase-1 (HO-1), SOD, glutathione S-transferase, and NAD(P)H quinone oxidoreductase 1