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Mechanisms Beyond Adiposity: The substantial MACE reduction not explained by weight or waist changes points to direct cardiovascular effects, including: Improved endothelial function and vascular health Anti-inflammatory pathways via central GLP-1 receptor signalling Favourable effects on blood pressure and lipid metabolism Possible early adipose tissue metabolic improvements before measurable mass reduction 3

doi: 10.1007/S12630-023-02440-3 109 FezzaRRainsBFezzaTFezzaJP

This presents a challenge when evaluating the test article for potential toxicological effects, since the test article is designed to produce decreased food consumption and body weight loss

Ozempic is one of many medications in the GLP-1 agonist class used to treat type 2 diabetes