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Contact your GP within 2448 hours if you experience headaches that progressively worsen despite simple painkillers, persist beyond 48 weeks of stable dosing, or significantly interfere with daily activities

it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia

Start by consulting a nephrologist to determine if these medications are a suitable option

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