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Response to certolizumab pegol in the RAPID-PsA trial was comparable to other TNF inhibitors in PsA, with 58% of the certolizumab pegol 200 mg every-2-weeks group and 51.9% of the certolizumab pegol 400 mg every-4-weeks group achieving an ACR20 at 12 weeks compared with 24.3% in the placebo arm (Figure 7-16)

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However, the magnitude of VEGF change and the upstream signaling pathway driving it are not established with the precision needed to predict dose-response in humans