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Several studies have suggested the involvement of connexin and hemichannel signaling in APAP-induced acute liver failure

Olsen et al

Biochem Biophys Res Commun 271 : 4753

Fruergaard Jrgensen acknowledged the criticism, particularly around the firm's failure to accurately communicate the flexible trial design, which raised questions over tolerability, with fewer than two-thirds of patients progressing to the highest dose after 68 weeks