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The two major incretins, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), are secreted from the intestinal enteroendocrine cells in response to nutrient intake

Novo CEO Mike Doustdar pushed back on the notion that those restrictions would limit uptake, telling CNBC in March that it was "absolutely not the case." "People are really interested because it's the most efficacious pill right now in the market," Doustdar added

Yerba mate does not produce, contain, or stimulate endogenous GLP-1 release in any meaningful way