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Weak acids such as penicillins and cephalosporins are highly ionized in plasma and therefore do not penetrate into the mammary gland very well, so these are most effective when administered by local infusion into the udder, where the extremely high local concentrations negate local pH effects

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Une carence peut donc survenir la suite d'une alimentation vgtale non complmente, ainsi que de certaines pathologies rduisant la capacit d'absorption telles que des maladies de l'estomac, du pancras, des intestins, du foie ou autres [31]