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It differs from the modest lean-mass reduction seen during weight loss, where the body adapts to lower energy needs

1a) and phosphorylated hormone-sensitive lipase (HSL) (ESM Fig

This difference in impact between GLP-1 receptor agonists and tirzepatide should be noted by practitioners when coprescribing tirzepatide with oral hormonal contraceptives, and appropriate patient education on the management of the interaction should be provided. For these reasons, it is important to counsel any woman prescribed a GLP-1 about pregnancy risks and recommend a reliable contraceptive method, such as long-acting reversible contraception, Finkle said

Like any medication, GLP-1s can cause side effects, especially in the early stages of treatment