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Clinical research and our own patient experiences show that weight loss with tirzepatide is typically steady over several months, with the most significant changes occurring between three and six months of consistent use

Specifically, patients on GLP-1RA or combination therapy exhibited greater reductions in body mass index (BMI), central systolic blood pressure (SBP), and arterial stiffness as assessed by pulse wave velocity (PWV)

These effects could potentially mitigate age-related cardiac decline and support overall heart health, though further studies are needed to confirm these benefits in humans

Although the risk is small, metaplasia makes cancerous changes more likely