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This results in the destabilizing of the closed state and the inappropriate activation of channels at low cytosolic Ca2+ concentrations, resulting in pathological endoplasmic/sarcoplasmic reticular Ca2+ leakage

What statins actually do inside the body Statins (HMG-CoA reductase inhibitors) block the enzyme HMG-CoA reductase, a key control point in the mevalonate pathway, the biochemical route the liver uses to make cholesterol

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