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133 In real-time polymerase chain reaction analyses, Kinoshita and Miyata 134 and Ho et al 135 observed weak CYP2E1 mRNA expression in liver tissue from patients with HCC, which may be related closely to tumor invasiveness and poor prognosis

The transporters are dependent on the pH in the intestines

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No significant changes were detected in the expression of classical thermogenic genes ( Ucp1 , Dio2 , Prdm16 ), creatine metabolism genes ( Ckmt1 , Ckmt2 ), or calcium cycling regulators ( Atp2a2 , Ryr1 , Ryr2 ) in BAT, eWAT, or iWAT (Supplementary Fig